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Does gluconeogenesis stimulate cortisol?

Junior Low-Carber

Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome.

Its primary functions are to increase blood sugar through gluconeogenesis, suppress the immune system, and aid in fat, protein, and carbohydrate metabolism

So obviously Cortisol does it but what are the effects? Cortisol is known in great numbers to be involved in fat storage,hunger promotion and insulin resistance among other things. By that stand, it would explain why initial weight loss in low carb diets eventually stops and there is even a rebound effect if one persists on strict low carb ketogenic diet.

I see that Jimmy has talked about gluconeogenesis before thinking it's a straightforward process but it turns there is a high price to pay in terms of elevated cortisol. This was my experience, low carb was good initially to stabilize blood sugar but I had to bring carbs back to lower cortisol . Bringing back carbs and doing only anaerobic exercise, mainly sprinting, lost me fat and gained me muscle the way no diet could.
So Jimmy , are you still proponent of GNG given this cortisol connection?

Senior Low-Carber

That says that elevated cortisol causes gluconeogenisis, but I did not see anyplace that the opposite was true. Have I missed something?

"No good days or bad days, just new days." Zel"

Expert Low-Carber

I'm not so sure it matters. Consistent VLC eating perpetuates a constant need for gluconeogenesis, a process our bodies "sense" as fasting/starvation. So there is certainly a correlation between the fasted state where gluconeogenesis is stimulated and cortisol is elevated.

Cortisol contributes to insulin resistance

My Carb Sane-Asylum (Science Stuff)
My Carb Sane Chronicles (Personal Stuff)

Advanced Low-Carber

One of cortisol's function is to augment the 'fight or flight' phenomenon. If you were being chased by a saber-tooth tiger you needed to run your fastest. To run your fastest you needed sugar. (Gluco--sugar Neo--new Gensesis--To Make.


Junior Low-Carber

low carb diet initiates cortisol as the lack of carbs leads to low blood glucose. Cortisol is a glucocorticoid which means it upregulates sugar when there is too little of it in the blood , hence low carb stimulates cortisol.

Junior Low-Carber

Cortisol increases blood sugar and supresses insulin clearout of excess blood sugar

Quote:By far the best known metabolic effect of cortisol and other glucocorticoids on metabolism is their ability to stimulate gluconeogenesis (a metabolic process in which glucose is formed from non-carbohydrate carbon substrates such as lactate , glycerol , and glucogenic amino acids by the liver). Cortisol often increases the rate of gluconeogenisis as much as 6-10 folds. Cortisol causes gluconeogenesis by increasing all the enzymes in the liver cell which are required to convert amino acids to glucose. Also, Cortisol causes mobilization of amino acids from the extra hepatic tissues (mainly muscles). As a result, more amino acids become available in the plasma to enter into the gluconeogenisis process of the liver and thereby to promote the formation of glucose. Not only this Cortisol causes a moderate decrease in the rate of glucose utilization by the cells every where in the body.